Tumor-related death is often associated with tumor metastasis. Metastasis process includes the acquisition of dissemination traits of tumor cells， dormancy awakening， and distant growth. Changing dissemination traits of cancer cells， maintaining and killing dormant tumor cells， editing pre-metastatic microenvironment， and reprogramming hallmarks of cancer will be key to block tumor metastasis. Bevacizumab， denosumab and cilengitide have been approved for clinical therapies. Tumor screening based on blood tests combined with artificial intelligence will provide new targeted metastasis strategies for clinical treatment.