Proton beam have been widely used in the field of tumor radiotherapy due to the significant physical dosimetric advantages. This series of studies enrolled typical tumor target areas，including the head and neck，whole central nervous system，lungs，esophagus，breast，abdominal and pelvic cavities，and developed both proton and photon radiotherapy plans to compare and evaluate the dosimetric characteristics provided by the two techniques. These studies aim to reflect the dosimetric differences between proton and photon radiotherapy，thus providing references for doctors' clinical decision-making and patients' medical choices.