Colorectal cancer （CRC） is one of the most common digestive system tumors and the second most common tumor in the world in terms of mortality. The current chemotherapeutic drugs applied in clinical treatment seriously affect the survival quality of patients due to adverse reaction and susceptibility to chemoresistance. Therefore，it is necessary to search for novel anti-CRC drugs. As natural compounds，polyphenols components of traditional Chinese medicine can exert anti-CRC properties through various mechanisms，such as promoting apoptosis，inhibiting cell proliferation，and inducing iron death. In addition，it can reverse the resistance of CRC cells to chemotherapeutic drugs. Further exploration of the anti-CRC action mechanism of polyphenols constituents of traditional Chinese medicine may provide a certain reference basis for clinical application.